Immunopharmacology and Immunotoxicology


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Naïve, protein-naïve and non-naïve study subjects
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Acute, short-infusion or repeated dosing designs.
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General, tissue and cell-specific toxicity evaluations
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Inflammation (standard and expanded multiplexed cytokine assays)
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Hypersensitivity, inflammatory and allergic reactions evaluations (e.g. CARPA, DTH and cytokine release syndrome)
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Complement activation pathways protein assays (single analyte or multiplexed)
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Tissue-specific efficacy biomarker levels by biosampling, biopsy or microdialysis.
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Cellular response assays (ELISpot, intracellular cytokines by flow cytometry)
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Immunophenotyping (generic PBMC distribution and comprehensive CD markers panels by flow cytometry)
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Biomarkers immunoassays (single analyte or multiplexed)
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Immunohistochemistry (cell surface or intracellular markers)
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Organ-specific or complete histology and pathology evaluation
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Anti-drug antibodies assays
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Full clinical pathology support