Surgical Capabilities
Surgical Excellence That Enables Complex, High-Impact Preclinical Studies
At Envol Biomedical, surgical precision is not an afterthought—it’s a cornerstone of our research model. Our team includes clinically trained surgical experts who enable the most sophisticated study designs in nonhuman primates (NHPs), helping sponsors achieve serial sampling, complex dosing, and targeted delivery that would otherwise be impossible.
Surgical capabilities at Envol are integrated into every major service line—pharmacology, pharmacokinetics, and toxicology—to support rigorous science with reduced animal use, better data continuity, and faster regulatory progress.
What Surgical Capabilities Enable at Envol
Our surgical platform allows for:
- Serial sampling from single animals over time
- Repeat dosing without compromising animal welfare
- Precise delivery to target organs or systems
- Custom model creation for translational disease studies
These capabilities improve study efficiency, reduce variability, and support advanced analytics such as PK modeling, PD response tracking, and longitudinal toxicology assessments.
Our Areas of Surgical Expertise
Envol’s surgical team supports a wide range of procedures and delivery routes, including:
Access and Sampling Procedures
- Vascular access port placement
- Arterial and venous catheterization
- CSF sampling via cisterna magna or lumbar access
- Bile duct cannulation (as needed)
Dosing Routes and Delivery Systems
- Intravenous (IV)
- Subcutaneous (SC)
- Intrathecal (IT)
- Intranasal (IN)
- Intracisternal (IC)
- Intraocular
- CNS-targeted dosing
These procedures are conducted under GLP or non-GLP protocols depending on sponsor requirements.
Supporting a Range of Study Types
Our surgical capabilities are embedded across all major programs:
- Pharmacokinetics (PK) – Serial sampling for drug distribution and exposure
- Toxicology – Complex dose administration and sampling in GLP tox studies
- Pharmacology – Surgical models for CNS, respiratory, or ocular indications
- Therapeutic Areas – Precise delivery for ASOs, mRNA therapies, and LNP-formulated compounds
We specialize in enabling advanced delivery systems required for genetic medicines, including lipid nanoparticle (LNP) delivery and viral vector administration.
Why Sponsors Choose Envol for Surgical Studies
- Clinical-grade surgical expertise in-house
- Complex dosing and repeat access designs
- Supports serial sampling and custom disease models
- Cross-functional coordination with lab, PK, and tox teams
- GLP and non-GLP compliance
Whether you're exploring a novel delivery method or simply need reliable access for long-term dosing and sample collection, Envol’s surgical team is ready to support your goals with precision and care.
Integrated Teams. Faster Execution.
Unlike facilities that outsource or silo surgical work, Envol’s in-house approach allows for:
- Tight coordination between surgeons, study directors, and lab teams
- Reduced startup times and scheduling delays
- Controlled environments for animal care and welfare
This internal integration helps us deliver faster results without sacrificing quality—a major advantage for sponsors with compressed timelines.
Recent Blogs
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Tell us about your compound and study needs—we’ll build a surgical plan that supports your science and your timeline.