Pharmacology Services

Translational Pharmacology Services for Drug Development in NHP Models

At Envol Biomedical, our pharmacology services are purpose-built for precision, speed, and scientific clarity—delivering the data you need to move confidently from discovery to IND-enabling studies. We specialize in the use of nonhuman primates (NHPs) to evaluate the effects of candidate therapies, leveraging advanced tools, surgical capabilities, and integrated analytics to generate high-quality, actionable insights.

We support both mechanistic pharmacology studies and disease model development, giving sponsors the flexibility to assess drug effects in normal physiology or in well-characterized translational models.

What Is Pharmacology at Envol?

Pharmacology is the study of how a drug interacts with a biological system. At Envol, this takes two primary forms:

Drug Effect Assessment (Pharmacodynamic Studies)

We evaluate how a compound alters biological systems in real time. Using advanced biomarker analysis, imaging, and physiologic readouts, we quantify:

Inflammatory markers
Cytokine expression
Cellular changes
Functional endpoints

These studies may occur in healthy NHPs or in combination with induced disease phenotypes, depending on the program’s goals.

Model-Based Disease Studies

We create or implement translational animal models that replicate key aspects of human disease. These include:

Metabolic disease models (e.g., obesity, body composition)
Inflammatory conditions
Other custom phenotypes using adjuvants or surgical interventions

These models are paired with drug treatment to assess therapeutic efficacy against disease-relevant endpoints.

Tools and Capabilities Supporting Pharmacology

Our pharmacology work is enhanced by cross-functional services that accelerate timelines and increase data reliability:

Surgical Capabilities: Complex dosing routes and serial sampling (e.g., vascular access ports, CNS delivery)
Core Laboratory Services: Bioanalytical chemistry, immunoassays, cytokine profiling, ELISAs, PCR/ddPCR, and more
Imaging: In vivo imaging to monitor physiological or anatomical drug effects
Custom Model Development: Use of adjuvants and phenotype validation protocols
Data Integration with Resero: Near real-time reporting and data analytics

Each study is tailored with a regulatory-aware mindset to ensure downstream success in preclinical development programs.

Why Envol Biomedical?

GLP and Non-GLP Study Capabilities
Vertically Integrated NHP Supply Chain
Surgical Expertise in CNS, Ocular, Respiratory Indications
Transparent Communication and Fast Turnaround
Validated Study Designs with Scientific Flexibility

Whether you're conducting exploratory pharmacology or confirming a therapeutic hypothesis, our team ensures you get clean, clear, and submission-ready data every step of the way.