Therapeutic Areas

Indication-Focused NHP Models for Advanced Drug Development

At Envol Biomedical, we specialize in nonhuman primate (NHP) studies tailored to specific therapeutic areas where translational relevance is critical. Our team supports sponsors working in some of the most challenging and high-impact fields in medicine—including neurology, ophthalmology, and respiratory disease—with validated models, advanced delivery techniques, and the infrastructure to move programs quickly and compliantly toward clinical translation.

Whether you’re developing a small molecule, biologic, or genetic medicine, we provide the surgical access, regulatory alignment, and biological endpoints needed to generate meaningful data.

Core Therapeutic Areas of Focus

We’ve built targeted expertise in several key indication areas, each supported by validated NHP models, surgical dosing capabilities, and integrated lab assessments.

Central Nervous System (CNS)

Envol offers deep experience in CNS-focused preclinical studies:

Intrathecal, intracisternal, and intranasal delivery
Behavioral, imaging, and biomarker endpoints
Surgical access for serial sampling and localized drug administration

Ideal for:

Neuroinflammation
Neurodegeneration
Antisense oligonucleotide (ASO) delivery
Gene therapy or gene editing approaches

Ocular

We support studies for drugs targeting the eye with:

Intraocular and periocular dosing
Surgical techniques for precision delivery
Histologic and imaging endpoints to assess safety and distribution

Applications include:

Retinal degeneration models
Ocular inflammation
Delivery of RNA therapeutics and biologics

Respiratory

Our respiratory models support inhaled, intranasal, and systemic therapies for diseases of the lung and airway:

Intranasal and aerosolized delivery techniques
Pulmonary inflammation and cytokine profiling
LNP- and vector-based delivery for respiratory gene therapies

Ideal for:

mRNA vaccines and therapeutics
Respiratory fibrosis or infection models
Delivery platform validation

Beyond Indications: Expertise by Drug Modality

Our therapeutic focus isn’t limited to disease areas—we also bring specialized experience across a wide range of drug classes:

mRNA therapeutics
ASOs and oligonucleotide drugs
Monoclonal antibodies and biologics
Small molecules
Gene therapy and gene editing platforms

We work with sponsors to ensure that each drug class is matched with the right model, delivery method, and analytical strategy to support both efficacy and safety.

Delivery System Integration

Our in-house team is highly experienced in the complex delivery systems required for modern therapeutics. We routinely support:

Lipid nanoparticles (LNPs)
Adenovirus and lentiviral vectors
Non-viral vector systems
Custom microsurgical dosing protocols

We are also a proud member of an active Lipid Nanoparticle Consortium, and we welcome cross-promotion opportunities with like-minded collaborators in the LNP delivery space.